Native soft tissue matrix for therapeutic applications

Matrice de tissu mou natif conçue pour des applications therapeutiques

Abstract

L'invention concerne un produit à implanter dans un site de tissu mou du corps humain ou animal, qui comprend une matrice pulvérisée ou en morceaux d'un tissu mou natif sensiblement non minéralisé (NSTM) du corps humain ou animal, fournie en dose thérapeutique pour induire la croissance d'un tissu natif ou d'organes et la guérison au niveau du site tissulaire. Le NSTM est composé d'au moins un tissu mou choisi dans le groupe constitué de cartilage, de ménisque, de disque intervertébral, de ligament, de tendon, de muscle, de fascia, de périoste, de péricarde, de périchondre, de peau, de nerfs, de vaisseaux sanguins et de valvules cardiaques ou à partir d'organes tels que la vésicule, les poumons, les reins, le foie, le pancréas, la thyroïde, ou le thymus. De préférence, le NSTM se compose d'un tissu mou du même type que le tissu natif du site de réparation. Dans un autre mode de réalisation, le NSTM comporte du tissu mou d'un type différent de celui du site de réparation.
A product for implantation within a soft tissue site of the human or animal body comprises a pulverized or morselized matrix of a substantially non-mineralized native soft tissue (NSTM) of the human or animal body, provided in a therapeutic amount to induce growth of native tissue or organs and healing at the tissue site. The NSTM is composed of at least one soft tissue selected from the group consisting of cartilage, meniscus, intervertebral disc, ligament, tendon, muscle, fascia, periosteum, pericardium, perichondrium, skin, nerve, blood vessels, and heart valves or from organs such as bladder, lung, kidney, liver, pancreas, thyroid, or thymus. Preferably, the NSTM is composed of a soft tissue of the same type of tissue native to the repair site. In another embodiment, the NSTM includes soft tissue of a different type than the tissue repair site.

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    US-8784863-B2July 22, 2014Zimmer, Inc.Particulate cadaveric allogenic cartilage system
    US-8834914-B2September 16, 2014Zimmer, Inc.Treatment methods using a particulate cadaveric allogenic juvenile cartilage particles
    US-9138318-B2September 22, 2015Zimmer, Inc.Apparatus for forming an implant